Joseph Larmarange

Becquet Valentine, Nouaman Marcellin, Plazy Mélanie, Masumbuko Jean-Marie, Anoma Camille, Kouamé Soh, Danel Christine, Eholié Serge and Larmarange Joseph (2019) “Sexual health needs of female sex workers reached by two NGOs in Côte d’Ivoire: considerations for the future implementation of PrEP” (communication orale), presented at the AIDS Impact, London. http://www.aidsimpact.com/abstracts/-LZFgxedD3IcXCPGWlOB.

Abstract: Aim In West Africa, most countries have mixed HIV epidemics; new tools such as pre-exposure prophylaxis (PrEP) should target in priority most affected populations, particularly female sex workers (FSWs). This paper describes sexual and reproductive health (SRH) needs of FSWs in Côte d’Ivoire to inform the future implementation of PrEP in this population. Method/Issue The ANRS 12361 PrEP-CI cross-sectional and mixed-methods study was designed and implemented with two Ivorian community-based organizations. 1000 FSWs completed a standardized questionnaire assessing women’s sociodemographic characteristics, sexual practices and behaviors, use of community health services, a priori acceptability of PrEP. Twenty-two in-depth interviews and eight focus group discussions were conducted at prostitution sites. FSWs were interviewed about risky practices and sexual behaviors, experiences with violence and discrimination, attitudes regarding HIV and sexually transmitted infections (STIs), and barriers to SRH services. Results/Comments The quantitative and qualitative results showed that FSWs were highly exposed to HIV despite their use of condoms with clients. 91% did not use condoms with their regular partner, despite their acknowledged concurrent sexual partnerships. 23% accepted condomless sexual intercourse for a large sum of money, especially when they had had few previous clients. Moreover, FSWs faced many unmet needs regarding SRH beyond HIV prevention and treatment. Inconsistent condom use exposed FSWs to STIs and undesired pregnancies. However, the prevalence of contraceptive use was low (40%) due to fear of contraception causing sterility. FSWs faced obstacles in accessing SRH care and preferred advice from their peers or self-medication. Discussion Implementing PrEP among FSWs in West Africa, such as in Côte d’Ivoire, constitutes an opportunity to consider the chronic follow-up of HIV-negative FSWs. PrEP initiation should not condition access to SRH services; conversely, SRH services could be a way to attract FSWs into practicing HIV prevention. Our results highlight the importance of developing a people-focused approach that integrates all SRH needs when transitioning from PrEP efficacy trials to implementation.

Bekelynck Anne, Carillon Séverine, Assoumou Nelly, Kouadio Alexis, Danel Christine, Ouantchi Honoré, Koné Mariatou and Larmarange Joseph (2019) “Pepfar 3.0’s HIV testing policy in Côte d’Ivoire (2014-2018): a changing strategy between improvement of testing yield and achievement of the first 90?” (communication orale), presented at the AIDS Impact, London. http://www.aidsimpact.com/abstracts/-LZtWmf5VK5Jr8HC_KPj.

Abstract: Aim Since 2014, the Pepfar has initiated its phase III called ‘Pepfar 3.0’ (2014- now), focusing on ‘Sustainable Control of the Epidemic’, to reach the Joint United Nations Programme on HIV/AIDS’ (UNAIDS) 90-90-90 goal. In this strategic plan, the Pepfar states that it is “pivoting to a data-driven approach that strategically targets geographic areas and populations where [they could] achieve the most impact for [their] investments”. In practice, how were these new targeted HIV screening strategies developed and what were the challenges encountered? Method/Issue We conducted a qualitative study in Côte d’Ivoire in 2015-2018, a country where the HIV program is mainly funded by the Pepfar (73% in 2018). In-depth interviews were conducted with stakeholders in the AIDS public response: CDC/Pepfar (3), Ministry of Health (3), intermediary NGOs (7); and we observed public meetings (nb). In addition, the grey literature of Pepfar (Country Operational Plan – COP, https://www.pepfar.gov/) was reviewed to describe the evolution of Pepfar’s HIV testing strategies from COP 14 to COP 17 (October 2014 – September 2018). Results/Comments Since the COP 14, Pepfar’s HIV testing strategies have been characterized by significant variations: (i) in the targets of the number of people and of HIV positive people to be screened, divided by 2 between COP 14 and COP 15 and multiplied by 4.5 between COP 15 and COP 17; (ii) in the targeted geographical areas, from a regional breakdown to an identification of health districts at high and low impact; and (iii) in the targeted sub-groups, from a focus on key populations to a broader definition of priority populations, including men over 25 years old. A shift was observed in the definition of testing targets, with less room dedicated to programmatic data and feedbacks from field actors and an increasing focus on the use of modelling work to estimate and disaggregate the targets by geographical units and sub-population (even if available data at these fine levels was limited and uncertain); increasingly leading to gaps between targets and results. While the aim of COP 14 and COP 15 seemed to be the improvement of testing efficacy in general and testing yield (i.e. testing positivity rate) in particular, COP 16 and 17 have given priority to fill the gaps in terms of the first 90 (i.e. reducing proportion of PLHIV being undiagnosed). Discussion This study highlights how the Pepfar approach has been changing over the last 5 years as a result of the tension between improving HIV testing yield and achieving the first 90 (90% of PLHIV being diagnosed) in the context of a mixed epidemic, combined with a context of limited resources implying to improve the “value for money” of policies. This study also underlines the limited possibility of very rapidly evolving strategies by the donor - emphasised by the annual system of COPs - in a context where actors have different adaptive capacities. The emphasis on targets to reach tends to underestimate the political and social modalities of

Bekelynck Anne and Larmarange Joseph (2019) “Pepfar 3.0’s HIV testing policy in Côte d'Ivoire (2014 to 2018): fragmentation, acceleration and disconnection”, Journal of the International AIDS Society, 22 (12), p. e25424. DOI : 10.1002/jia2.25424. https://onlinelibrary.wiley.com/doi/abs/10.1002/jia2.25424.

Abstract: Introduction HIV Testing and Counselling (HTC) remains a key challenge in achieving control of the HIV epidemic by 2030. In the early 2010s, the President's Emergency Plan for AIDS Relief (Pepfar) adopted targeted HTC strategies for populations and geographical areas most affected by HIV. We examine how Pepfar defined targeted HTC in Côte d'Ivoire, a country with a mixed HIV epidemic, after a decade of expanding HTC services. Methods We explored the evolution of HTC strategies through the Country Operational Plans (COP) of Pepfar during its phase 3.0, from COP 14 to COP 17 (October 2014 to September 2018) in Côte d'Ivoire. We conducted an analysis of the grey literature over the period 2014 to 2018 (Budget & Target Report, Strategic Direction Summary, Sustainability Index and Dashboard Summary, https://data.pepfar.gov). We also conducted a qualitative study in Côte d'Ivoire (2015 to 2018) using in-depth interviews with stakeholders in the AIDS public response: CDC/Pepfar (3), Ministry of Health (3), intermediary NGOs (7); and public meeting observations (14). Results Since the COP 14, Pepfar's HIV testing strategies have been characterized by significant variations in terms of numerical, geographical and population targets. While the aim of COP 14 and COP 15 seemed to be the improvement of testing efficacy in general and testing yield in particular, COP 16 and COP 17 prioritized accelerating progress towards the “first 90” (i.e. reducing the proportion of people living with HIV who are unaware of their HIV). A shift was observed in the definition of testing targets, with less focus on the inclusion of programmatic data and feedback from field actors, and greater emphasis on the use of models to estimate and disaggregate the targets by geographical units and sub-populations (even if the availability of data by this disaggregation was limited or uncertain); increasingly leading to gaps between targets and results. Conclusions These trials and tribulations question the real and long-term effectiveness of annually-revised, fragmented strategies, which widen an increasing disparity between the realities of the actors on the ground and the objectives set in Washington.

Tags: Africa, COP (Country operational Plan), Côte d'Ivoire, Health policy, HIV testing, Pepfar.

Calmettes Sophie and Larmarange Joseph (2019) “ATLAS : implementing and evaluating HIV self-testing in West Africa - an example of Community-based Action Research” (communication orale), presented at the Pre-confernence "Community-based Action Research : What can we learn from the HIV field experiences from the Global North and the Global South ?" at 12th European Public Health Conference, Marseille. https://ephconference.eu/2019-pre-conference-208.

Carillon Séverine, Bekelynck Anne, Assoumou Nelly, Kouadio Alexis, Danel Christine, Ouantchi Honoré, Koné Mariatou and Larmarange Joseph (2019) ““We need incentives!” Health care professionals’ reluctance to propose systematically HIV testing during general consultation in Cote d’Ivoire” (poster), presented at the AIDS Impact, London. http://www.aidsimpact.com/abstracts/-LZtpxecQfo45SlC9BNU.

Abstract: Aim To increase access to HIV testing, WHO recommended in 2007 provider-initiated HIV testing using a simplified but still exceptional approach in terms of pre-test counseling and consent. Cote d’Ivoire accepted in 2009 systematic HIV testing proposal in all medical consultations, irrespective of reasons. What are health care professionals (HCPs) perceptions and experiences related to testing proposal? Method/Issue An ethnographic multi-site study was conducted in 3 general medical services (urban, semi-urban, rural) in 2 Ivorian health districts: 37 in-depth interviews with HCPs and 200 observed medical consultations (general medicine). A thematic analysis was performed on HCPs’ practices and discourses. Results/Comments The proportion of patients offered an HIV test was low (around 20%), due to HCPs’ reluctance to propose an HIV test in the absence of clinical suspicion. When offered, HIV test was more often prescribed than proposed. The analysis revealed 4 types of explanations in HCPs discourses. (1) Due to stigma associated to HIV, HCPs feared a negative reaction from their patients: refusal, offence, distrust, loss of patients. (2) Time-consuming specificity of HIV testing in terms of counseling, consent and administrative procedure (separate record and dedicated prescription) is perceived by HCPs as not useful and inducing a work overload that should be financially compensated or realized by dedicated providers, as it was before 2009. (3) In the absence of clinical suspicion, they considered that proposing an HIV test during a general consultation is not medically justified and not their priority. (4) Finally, HCPs felt that they are not sufficiently trained. Discussion HCPs experiences and perceptions are negatively affected by the legacy of the successive HIV policies implemented since the beginning of the epidemy. Some complex procedures, historically implemented due to confidentiality and stigma issues, could maybe be simplified today. Integrating HIV testing in routine is a challenge considering that these activities were previously implemented with dedicated incentives, training and human resources. In a context of limited resources and mixed epidemic, how to prioritize and reorganize HIV testing in general consultations while motivating HCPs and being efficient in terms of public health?

Doumenc Aïdara Clémence and Larmarange Joseph (2019) “ATLAS Project : adapting HIVST distribution models in West Africa to reach those left behind” (communication orale), presented at the 20th ICASA, Kigali. https://www.icasa2019rwanda.org/.

Gosset Andréa, Protopopescu Camelia, Larmarange Joseph, Orne-Gliemann Joanna, McGrath Nuala, Pillay Deenan, Dabis François, Iwuji Collins and Boyer Sylvie (2019) “Retention in Care Trajectories of HIV-Positive Individuals Participating in a Universal Test-and-Treat Program in Rural South Africa (ANRS 12249 TasP Trial)”, JAIDS Journal of Acquired Immune Deficiency Syndromes, 80 (4) (April 1), p. 375. DOI : 10.1097/qai.0000000000001938. https://journals.lww.com/jaids/Fulltext/2019/04010/Retention_in_Care_Trajectories_of_HIV_Positive.2.aspx.

Abstract: Objective: To study retention in care (RIC) trajectories and associated factors in patients eligible for antiretroviral therapy (ART) in a universal test-and-treat setting (TasP trial, South Africa, 2012–2016). Design: A cluster-randomized trial whereby individuals identified HIV positive after home-based testing were invited to initiate ART immediately (intervention) or following national guidelines (control). Methods: Exiting care was defined as ≥3 months late for a clinic appointment, transferring elsewhere, or death. Group-based trajectory modeling was performed to estimate RIC trajectories over 18 months and associated factors in 777 ART-eligible patients. Results: Four RIC trajectory groups were identified: (1) group 1 “remained” in care (reference, n = 554, 71.3%), (2) group 2 exited care then “returned” after [median (interquartile range)] 4 (3–9) months (n = 40, 5.2%), (3) group 3 “exited care rapidly” [after 4 (4–6) months, n = 98, 12.6%], and (4) group 4 “exited care later” [after 11 (9–13) months, n = 85, 10.9%]. Group 2 patients were less likely to have initiated ART within 1 month and more likely to be male, young (<29 years), without a regular partner, and to have a CD4 count >350 cells/mm3. Group 3 patients were more likely to be women without social support, newly diagnosed, young, and less likely to have initiated ART within 1 month. Group 4 patients were more likely to be newly diagnosed and aged 39 years or younger. Conclusions: High CD4 counts at care initiation were not associated with a higher risk of exiting care. Prompt ART initiation and special support for young and newly diagnosed patients with HIV are needed to maximize RIC.

Inghels Maxime, Kra Kouassi Arsène, Niangoran Serge, Bekelynck Anne, Carillon Séverine, Danel Christine, Sika Lazare, Koné Mariatou, Desgrées du Loû Annabel and Larmarange Joseph (2019) “Cascade of provider-initiated HIV testing and counselling at specific life events (pregnancy, STIs, marriage plan) in Côte d’Ivoire” (poster), presented at the AIDS Impact, London. http://www.aidsimpact.com/abstracts/-LZpZjJNQzSUV6vuH4Ku.

Abstract: Aim In Côte d’Ivoire, only 57.8% of women and 37.0% of men have been HIV-tested at least once, which is insufficient to control the epidemic. The objective of this study is to describe at a population level if an HIV test was offered and performed at specific life-events where provider-initiated HIV testing is recommended. Method/Issue A cross-sectional telephone survey was conducted in 2017 among a representative sample of 3 867 individuals from the general population in Côte d'Ivoire. For each individual, the occurrence of the following events over the past 5 years was documented: birth of a child, Sexually Transmitted Infections—STIs, marriage. For each of these events, they were asked (i) if they have consulted a health professional, (ii) if they were offered an HIV test during that consultation and (iii) if they accepted it. The factors associated with each of these three steps were analyzed in separate logistic regression models stratified by type of event. Results/Comments While 63.7% of women were HIV-tested during their last pregnancy, only 16.9% of men were tested during their partner’s last pregnancy and this proportion fell to 13.4% for people with an STI and 14.5% for people who got married. These levels of HIV testing were mainly driven by a lack of medical consultation (except for pregnant women) and a lack of testing proposal (except for pre-marital check-up). Testing acceptability was high. Discussion Improving HIV testing coverage in Côte d’Ivoire requires (i) facilitating attendance to health services in case of STIs, marriage plans and pregnancy—for men—and (ii) strengthening routine testing proposal during these occasions.

Inghels Maxime, Kra Kouassi Arsène, Niangoran Serge, Bekelynck Anne, Carillon Séverine, Sika Lazare, Danel Christine, Koné Mariatou, Desgrées du Loû Annabel and Larmarange Joseph (2019) “Practices and Barriers to Provider-initiated HIV Testing and Counseling (PITC) among Midwives, Nurses and Physicians in Côte d'Ivoire” (poster WEPEC215), presented at the 20th ICASA, Kigali. http://www.professionalabstracts.com/icasa2019/iplanner/#/presentation/2236.

Abstract: Background: Despite the implantation of Provider Initiated Testing and Counselling (PITC) in 2009, testing proposal remains lows in Cote d'Ivoire, even in recommended situations. The purpose of this study is to identify the practices and obstacles to PITC among midwives, nurses and physicians in Côte d´Ivoire. Methods: A nationally representative cross-sectional survey was conducted in 2018 by telephone among three separate samples of midwives, nurses and physicians practicing in Côte d´Ivoire. The number of HIV tests proposed during consultation in the month preceding the survey was collected for each professional. Factors associated with the number of proposed tests were identified through ordinal logistic regression models. These factors were classified in three dimensions according to the conceptual framework of work performance (Motivation-Capability-Opportunity). Results: A total of 298 midwives, 308 nurses and 289 physicians were interviewed. Midwives proposed the test more frequently, followed by nurses and physicians. Among midwives, a higher number of proposed test was associated with the perceptions (motivation dimension) that HIV testing do not require a specific consent compared to other diseases (aOR 4,00 [95% CI 1.37-14.29]). Among nurses, having received a HIV training (i.e. capability) and the presence of community HIV counselors (i.e. opportunity) was associated with a higher number of proposed tests (aOR 2.03 [1.33-3.12] and aOR 1.86 [1.21-2.87] respectively). For physicians, the presence of a voluntary testing center (i.e. opportunity) was associated with a higher number of proposed tests (aOR 1.69 [1.01-2.86]). Conclusion: PITC practices and barriers were different across professions. Beyond improving environmental opportunities such as dedicated staff or services, strengthening the motivations and capabilities of healthcare professionals to propose testing could improve PITC coverage.

Larmarange Joseph (2019) “De PrEP-CI à PRINCESSE… construction d’une offre en santé sexuelle et reproductive à destination des travailleuses du sexe en Côte d’Ivoire” (communication orale), presented at the Journée d'études “La Recherche en sciences sociales sur la prophylaxie pré-exposition (PrEP)”, Paris. https://shsvih.hypotheses.org/1442.

Larmarange Joseph (2019) “Ggplot2 ou la grammaire des graphiques sous R” (communication orale), presented at the Rencontres de statistique appliquée de l'Ined, Paris. DOI : 10.5281/zenodo.3247913. https://larmarange.github.io/seminaire-INED-18juin2019/diaporama.html.

Abstract: R possède un puissant moteur graphique interne. Toutefois, produire un graphique complet avec les fonctions basiques de R est peu aisée. L’extension ggplot2, développée par Hadley Wickham et mettant en œuvre la grammaire des graphiques théorisée par Leland Wilkinson, est devenue en quelques années l’une des extensions R les plus utilisées. La grammaire des graphiques invite l’utilisateur à repenser sa manière de concevoir un graphique en associant variables (données), paramètres graphiques (esthétiques) et formes géométriques, puis en complexifiant progressivement son graphique (coordonnées, échelles, facettes, étiquettes, légendes, thèmes…).

Larmarange Joseph (2019) “Les travailleuses du sexe en Afrique de l'Ouest, une population impliquée dans la dynamique de l'épidémie : des études observationnelles à PRINCESSE” (communication orale), presented at the Séminaire ANRS : Recherches sur le VIH/sida et les hépatites virales, quels nouveaux enjeux ?, Paris.

Larmarange Joseph (2019) “Quelle place pour les autotests VIH dans les pays à faibles ressources ?” (communication orale), presented at the AFRAMED, Casablanca. http://www.aframed2019.org.

Larmarange Joseph (2019) “The edges of key populations: how to think, describe and reach these hidden groups?” (communication orale en session plénière), presented at the AIDS Impact, London. http://www.aidsimpact.com/abstracts/-LcerHcNPqtU5HdgnxjE.

Abstract: In many settings, key populations (in particular men having sex with other men, sex workers and drug users) are overwhelmingly affected by HIV and many programs are focusing on them. Due to epidemiological modelling and policy planning, these groups are too often seen as socially homogeneous groups rather than heterogeneous categories with fuzzy outlines. Identities, social life, sexual practices, exposure to HIV varies within these groups, in particular between the core and the edges. Their sexual networks are also connected to individuals not perceived as “key populations”: female partners of bisexual men, regular partners and clients of sex workers, sexual partners of drug users… Could we better conceptualize the edges of key populations? What do we know about them? What is their role in the dynamic of HIV epidemics? How can we include them in the HIV response? Are some interventions more relevant to reach them?

Larmarange Joseph, Diallo Mamadou H, McGrath Nuala, Iwuji Collins, Plazy Mélanie, Thiébaut Rodolphe, Tanser Frank, Bärnighausen Till, Orne-Gliemann Joanna, Pillay Deenan, Dabis François and ANRS 12249 TasP Study Group (2019) “Temporal trends of population viral suppression in the context of Universal Test and Treat: the ANRS 12249 TasP trial in rural South Africa”, Journal of the International AIDS Society, 22 (10) (October 22), p. e25402. DOI : 10.1002/jia2.25402. https://onlinelibrary.wiley.com/doi/full/10.1002/jia2.25402.

Abstract: Abstract Introduction The universal test-and-treat (UTT) strategy aims to maximize population viral suppression (PVS), that is, the proportion of all people living with HIV (PLHIV) on antiretroviral treatment (ART) and virally suppressed, with the goal of reducing HIV transmission at the population level. This article explores the extent to which temporal changes in PVS explain the observed lack of association between universal treatment and cumulative HIV incidence seen in the ANRS 12249 TasP trial conducted in rural South Africa. Methods The TasP cluster-randomized trial (2012 to 2016) implemented six-monthly repeat home-based HIV counselling and testing (RHBCT) and referral of PLHIV to local HIV clinics in 2 ? 11 clusters opened sequentially. ART was initiated according to national guidelines in control clusters and regardless of CD4 count in intervention clusters. We measured residency status, HIV status, and HIV care status for each participant on a daily basis. PVS was computed per cluster among all resident PLHIV (≥16, including those not in care) at cluster opening and daily thereafter. We used a mixed linear model to explore time patterns in PVS, adjusting for sociodemographic changes at the cluster level. Results 8563 PLHIV were followed. During the course of the trial, PVS increased significantly in both arms (23.5% to 46.2% in intervention, +22.8, p < 0.001; 26.0% to 44.6% in control, +18.6, p?

Tags: antiretroviral therapy, HIV, population health, retention in care, South Africa, sustained viral suppression.

Larmarange Joseph (2019) “Conférence mondiale sur le VIH-Sida à Mexico : « l'autotest » testé en Afrique”Simon Rozé, RFI (Radio france internationale). http://www.rfi.fr/science/20190723-vih-sida-congres-scientifique-mexique-questions-venezuela-cote-ivoire.

Nouaman Marcellin, Becquet Valentine, Masumbuko Jean-Marie, Anoma Camille, Soh Kouamé, Plazy Mélanie, Danel Christine, Eholié Serge and Larmarange Joseph (2019) “Female sex workers and HIV acquisition in Côte d’Ivoire: the burden of precariousness and working conditions (ANRS 12361 PREP-CI)” (poster discussion), presented at the INTEREST Workshop, Accra.

Abstract: Background Female sex workers (FSW) are a population at high risk of HIV acquisition. New tools to diagnose recent HIV infection may be used to better describe risk of HIV acquisition in this group. The ANRS 12361 PrEP-CI project aimed to estimate HIV incidence and describe risk factors among FSW in Côte d'Ivoire. Methods The study was conducted between September 2016 and March 2017 among FSW aged ≥18 years old in Abidjan and San Pedro. Two rapid tests for recent HIV infection (Determine®, Alere and Vikia®, bio Mérieux) were offered to FSW; in case of positive result, a dried blood sport was collected and window period of infection determined using a test for recent infection (EIA-RI) adapted to the Ivorian context. A standardized sociodemographic questionnaire was then administered to FSW by female peer educators, completed with qualitative interviews and focus groups with 60 FSW. Results 1000 SW (400 in San Pedro and 600 in Abidjan) with a median age of 25 years (interquartile range: 21-29) were included in the study and screened for HIV. Of these, 39 were diagnosed with HIV, 7 of which were newly infected (mean duration of infection was 113 days), corresponding to an HIV incidence of 2.3% [95% confidence interval: 1.6 - 3.1%]. The incidence was higher in San Pedro (3.3% [2.2-4.5]) than in Abidjan (1.6% [1.1-2.2]); this can be explained by qualitative data in which FSW in San Pedro expressed difficulties (distance, time, costs ...) in accessing health care services and prevention methods, particularly regarding condoms. HIV infection was also associated with vulnerability: the incidence was higher among those who charged ≤ 2000 CFA francs per intercourse (3.3% vs. 0.7%), those who performed on the streets or in hotels (5.4% and 4.2%, respectively, vs. 3.9% in brothel and 0.8% in bar – drinking spot), and among those who had more than 5 clients the last working day (6.1% vs. 1.8% among those who had under 5 clients) and who could be more difficult to identify and refer to HIV prevention services by female peer educators. Finally, FSW under <25 years old were at higher risk of infection (2.8%) than older ones (1.8%), and HIV incidence was associated with other sexually transmitted infections (STI) (2.5% in those who had ≥ 1 STI in the last 12 months vs. 1.9%). Contrary to expectations, an extensive sex work experience did not reduce exposure to HIV, when we compared FSW who had been working for more than 3 years with the ones who had newly arrived in the sex work industry (2.5% vs. 2.0%). Conclusion This study is one of the first to estimate HIV incidence in Côte d'Ivoire among FSW. This key population is much more exposed than the rest of the general population (2.3% vs. 0.06% estimated by UNAIDS). New infections seem to concentrated among younger FSW in precarious situations and working in remote areas, such as San Pedro area. These vulnerable subgroups should therefore be a priority target for prevention programs such as pre-exposure prophylaxis (PrEP) as recommended by WHO.

Pannetier Julie, Marsicano Élise, Larmarange Joseph and Broqua Christophe (2019) “Homo/bisexualités et migrations de l'Afrique subsaharienne à la France : quelles émancipations ?” (communication orale), presented at the 2e congrès international de l'Institut du Genre, Anger. https://congresgenre19.sciencesconf.org/.

Abstract: Dans une majorité de pays d'Afrique subsaharienne, les pratiques homosexuelles sont socialement condamnées, voire illégales. La migration vers un pays d'Europe peut constituer une opportunité de vivre différemment son homo-bisexualité, et ce, que la question de l'homosexualité soit ou non le moteur de la migration. Les liens entre homo/bisexualités et migrations ont jusqu'ici été peu explorés. Quelles sont les trajectoires des personnes migrantes ayant eu des relations homosexuelles au cours de leur vie ? Comment les relations avec des partenaires de même sexe s'inscrivent-elles dans les trajectoires relationnelles dans le pays d'origine et en contexte migratoire ? Dans quelle mesure la migration influe-t-elle sur les relations affectives et sexuelles ? Donne-t-elle accès à de meilleures conditions de vie et/ou de soins ? Nous souhaitons travailler ces questions à partir de l'enquête Parcours 2012-2013 qui porte sur les migrations subsahariennes en Île-de-France et la santé de ces populations, notamment les pathologies VIH et l'hépatite B. Dans cette enquête biographique, les parcours migratoire, résidentiel, juridique, économique, les relations affectives et sexuelles et les trajectoires de santé ont été collectés tout au long de la vie. Cela permet de reconstruire sous la forme d'un « récit de vie », le cheminement des personnes ayant déclaré au moins un partenaire de même sexe au cours de leur vie, soit 12 femmes et 23 hommes et de décrire leurs trajectoires, dans leurs diversités.

Pizarro Louis and Larmarange Joseph (2019) “Dépistage des populations cibles du VIH au Mali, au Sénégal et en Côte d’Ivoire” (communication orale), presented at the 13e Rencontres Nord-Sud IMEA/IRD, Paris.

Rolland Matthieu, McGrath Nuala, Tiendrebeogo Thierry, Larmarange Joseph, Pillay Deenan, Dabis François, Orne-Gliemann Joanna and Group for the ANRS 12249 TasP study (2019) “No effect of test and treat on sexual behaviours at population level in rural South Africa”, AIDS, 33 (4) (March 15), p. 709. DOI : 10.1097/qad.0000000000002104. https://journals.lww.com/aidsonline/Abstract/2019/03150/No_effect_of_test_and_treat_on_sexual_behaviours.14.aspx.

Abstract: Context: Within the community-randomized ANRS 12249 Treatment-as-Prevention trial conducted in rural South Africa, we analysed sexual behaviours stratified by sex over time, comparing immediate antiretroviral therapy irrespective of CD4+ cell count vs. CD4+-guided antiretroviral therapy (start at CD4+ cell count > 350 cells/μl then >500 cells/μl) arms. Methods: As part of the 6-monthly home-based trial rounds, a sexual behaviour individual questionnaire was administered to all residents at least 16 years. We considered seven indicators: sexual intercourse in the past month; at least one regular sexual partner in the past 6 months; at least one casual sexual partner in the past 6 months and more than one sexual partner in the past 6 months; condom use at last sex (CLS) with regular partner, CLS with casual partner, and point prevalence estimate of concurrency. We conducted repeated cross-sectional analyses, stratified by sex. Generalized Estimating Equations models were used, including trial arm, trial time, calendar time and interaction between trial arm and trial time. Results: CLS with regular partner varied between 29–51% and 23–46% for men and women, respectively, with significantly lower odds among women in the control vs. intervention arm by trial end (P < 0.001). CLS with casual partner among men showed a significant interaction between arm and trial round, with no consistent pattern. Women declared more than one partner in the past 6 months in less than 1% of individual questionnaires; among men, rates varied between 5–12%, and odds significantly and continuously declined between calendar rounds 1 and 7 [odds ratio = 4.2 (3.24–5.45)]. Conclusion: Universal Test and Treat was not associated with increased sexual risk behaviours.