journalArticle Becquet Valentine Nouaman Marcellin Plazy Mélanie Agoua Aline Zébago Clémence Dao Hervé Montoyo Alice Jary Aude Coffie Patrick A. Eholié Serge Larmarange Joseph and the ANRS 12381 PRINCESSE team Côte d’Ivoire HIV prevention Mixed-methods research Mobile clinics Pre-exposure prophylaxis (PrEP) Sex work Sexual and reproductive health Sexually transmitted infections (STIs), hepatitis B A community-based healthcare package combining testing and prevention tools, including pre-exposure prophylaxis (PrEP), immediate HIV treatment, management of hepatitis B virus, and sexual and reproductive health (SRH), targeting female sex workers (FSWs) in Côte d’Ivoire: the ANRS 12381 PRINCESSE project Pre-exposure prophylaxis (PrEP) is recommended by the WHO for HIV prevention among female sex workers (FSWs). A study conducted in 2016–2017 in Côte d’Ivoire showed that if PrEP is acceptable, FSWs also have many uncovered sexual health needs. Based on this evidence, the ANRS 12381 PRINCESSE project was developed in collaboration with a community-based organization. The main objective is to develop, document, and analyze a comprehensive sexual and reproductive healthcare package among FSWs in Côte d’Ivoire. 2214 2021-12-04 A community-based healthcare package combining testing and prevention tools, including pre-exposure prophylaxis (PrEP), immediate HIV treatment, management of hepatitis B virus, and sexual and reproductive health (SRH), targeting female sex workers (FSWs) in Côte d’Ivoire https://doi.org/10.1186/s12889-021-12235-0 2021-12-06 09:35:55 BioMed Central All rights reserved BMC Public Health 21 1 BMC Public Health DOI 10.1186/s12889-021-12235-0 ISSN 1471-2458